High density lipoprotein's role and why drugs can't enhance it

This morning, Eli Lilly announced that evacetrapib, its experimental drug to raise good cholesterol, failed to prevent patients from getting heart attacks and strokes in a large clinical trial. It is the third similar medicine to fail in expensive studies by three different drugmakers. This is dashing hopes for a new kind of treatment that might have helped millions of patients and calls into question the risky tendency of pharmaceutical executives spending billions of dollars on drugs that have no possibility of succeeding.

The body produces more HDL when a person exercises.  The body responds to exercise by producing muscle tissue and getting rid of excess fat. HDL particles transfer the excess fat away from cells, artery walls and tissues to the liver for disposition. Epidemiological studies have shown that high concentrations of HDL (over 60 mg/dL) have protective value against cardiovascular diseases such as ischemic stroke and myocardial infarction. Data from the landmark Framingham Heart Study showed that, for a given level of LDL, the risk of heart disease decreases 10-fold as the HDL goes from low to high.

People who have high HDL usually have a strong and healthy heart. The dumb thing doctors and pharmaceutical companies do is mis-infer the connection between HDL and a healthy heart. They assume, wrongly, that the heart is healthy because there is high HDL. The reality is that as the person does intensive cardio exercises, his heart gets stronger. His body starts building and maintaining muscle tissue. It starts getting rid of the excess fat in the body. The HDL concentration is increased.

Exercise and increase your HDL. I am giving this information for free. Pharmaceutical executives have spent $1.8 billion (with a "B") finding out that their assumption that increasing HDL will get the heart stronger- is wrong.


Bomi Joseph